Utilization Evaluation of the Prophylactic Antibiotic in Gynecologic Surgeries in Alzahra Hospital in 1396

Abstract

The rational use of drugs is the general goal of health system, as it may have important economic, clinical and outcomes. The use of antibiotics before surgery as a prevention of post-operative infection is one of the important factors in surgery. The use of antibiotics irregularly causes more resistance of microorganisms. Study the pattern of antibiotics administration before surgery is critical as surgical site infections are commonly preventable complications of surgery. Objective: Evaluation of the use of antibiotic prophylaxis regimens in patients undergoing general gynecological surgery in Tabriz Al-Zahra Hospital and their compliance with the International Standard of ASHP. Method: This was a cross-sectional study that conducted over a 6-month period (July 2017 to January 2018) in Tabriz's Al-Zahra Hospital. Prophylactic antibiotic regimens administered to patients evaluated and compared with the international standard of ASHP. Results: Over a period of 6 months, 210 patients from women undergoing general gynecological surgery were studied. The mean age of patients was 35.3±10.9 years. Cesarean section and hysterectomy were the most common procedures. Approximately 71.4% of the prophylaxis antibiotic regimen was compatible with the international standard of ASHP. The most commonly used antibiotic was cefazolin. The main problem in this study was the administration of an inappropriate dose of antibiotics, as only clindamycin and metronidazole were prescribed in accordance with the international standard of ASHP. Duration of antibiotic therapy in this center was more than 24 hours after surgery in 42% of cases. Conclusion: Antibiotic prophylaxis administration pattern needs to be evaluated by gynecologists and clinical pharmacists.