Drug Utilization Evaluation of Surfactant in Neonatal Intensive Care Unit (NICU) of Alzahra Teaching Hospital Tabriz.

Abstract

Respiratory distress syndrome (RDS) mostly occurs within preterm neonates. The main cause of RDS is surfactant deficiency .This deficiency causes inability in making sufficient functional residual capacity and infected lungs tendency to atelectasis due to extreme increase of surface tension. Aim: The purpose of this study was to investigate the pattern of administration of surfactant in premature infants admitted to the NICU. Material and Methods: This is a cross-sectional study and was performed on premature infants admitted to the NICU of Alzahra Hospital in Tabriz, who received surfactant, during the period from August 2017 to March 2018. Data collection was carried out using and clinical records of patients. The data were collected and evaluated based on the European Consensus Guideline on the management of respiratory syndrome ,2016. Results: Within 8 months, 252 infants who were admitted to the NICU and received surfactant were evaluated. Of the preterm infants, 57.1% were male and 42.9% were female. 73% of newborns were born before the 34th week of gestation and 27% before the 37th week of gestation. 80.6% of newborns were born by cesarean section. The most commonly used surfactant (Porcineuron alfa) was curosurf, which was used in 86.1% of cases. According to the pattern of use of surfactant, the prescribing of the drug based on the European Consensus Guideline was 79% and 82%, with good supervision from the Alzahra Hospital. Discussion: One of the strategies to reduce RDS is the prevention of premature births Also, the use of antenatal corticosteroid in mothers at risk for early delivery can improve survival and reduce the risk of respiratory distress in newborns. Non-invasive ventilation, including CPAP, also reduces the use of surfactants. Conclusion: Use of surfactants based on the birth weight of the baby and the volume of vials available to be cast effectively