Drug Utilization Evaluation of Antibiotics and Antifungals in Shahid Ghazi hospital from January till April 2016

Abstract

Introduction: There is a relation between amounts of antibiotic uses and creation of resistant bacteria. Due to the critical role of antibiotics and increasing trend of resistance in developing countries, comprehensive methods of antibiotic use is necessary to limit the threat of resistant microorganisms. In this study we compare antibiotics consumption by Defined Daily Dose (DDD) per 100 bed-days in Shahid Ghazi hospitals during three months in Tabriz, Iran. Aim: the comparison of Drug utilization and evaluation of antibiotics and antifungals in shahid ghazi hospital with the other hospitals in the world. Methods: This is a retrospective study, which enrolled patients with malignancy who admitted to Shahid Ghazi hospital from march January till April 2016. From all, 58 patients diagnosed with malignancy and received antibiotics for prophylaxis and/or treatment. The accurance of antibiotics consumption were assess by NCCN(2.2015) guideline. Amount of their antibiotic consumption obtained from the hospital pharmacies. Anatomical Therapeutic Chemical (ATC) code J01 was explained as defined daily doses per 100 bed-days (DDD/100) according to the ATC/DDD classification. The amount of consumption was assessed with DDD per 100 bed-days in three months. Results: from 56 patients, 46 of them had hematologic malignancy and 10 of them had solid tumors. The indication of antibiotics and antifungal prophylaxis were wrong in 19.6% of indications. The prophylaxis dosage of antibiotics, antifungal, antiviral and PCP were wrong in 8.8%, 41.7%, 80% and 50% respectively. The prophylaxis duration of antibiotics, antifungal, antiviral and PCP were wrong in 69.4%, 61.2%, 80% and 100% respectively. From all patients 75% of them received antibiotics. Conclusion: Specific strategies should be employed in infection control development and engage rational antibiotic utilization in order to reduce future resistant strains and increase antimicrobial efficacy.