Evaluation of the correlation between serum levels of vitamin D with blood pressure levels and quality of life in overweight and obese patients with type 2 diabetes in comparison with non-diabetic healthy subjects

Abstract

The purpose of this study was to determine the relationship between serum vitamin D level and systolic and diastolic blood pressure in type 2 diabetic patients with overweight and obesity. Materials and Methods: The case-control study was made up of 85 individuals in each group. Patients in the case group are overweight and obese type 2 diabetic patients who were included in the study according to entry and exit criteria. People with overweight and obesity who were matched for age and body mass index were included in the study. At first and after obtaining informed consent, all subjects were asked to complete a questionnaire containing individual information. The weight and height of each individual were measured. Measurement of nutrition status was carried out by experienced questioner through 24-hour food retrieval. The blood pressure of people sitting in a sitting position after five minutes of rest was measured from the right arm. Blood samples were measured by a lab expert to measure serum vitamin D level in Imam Reza Hospital, Tabriz. Quality of Life Questionnaire (36-SF: Short Form 36) was used to assess quality of life. The relationship between serum vitamin D level and blood pressure and quality of life in diabetic patients was compared with non-diabetic patients using appropriate statistical methods. Result: A total of 80 patients with diabetes mellitus type 2, overweight and obese, and 77 healthy controls without diabetes were evaluated. The mean age in the case group was 58.23 ± 10.83 and 55.53 ± 10.55 years in the control group. The mean BMI in the case group was 32.26 ± 5.91 kg / m2 and in the control group 31.01 ± 3.40 kg / m2 (p = 0.109). There was a significant statistical difference between the two groups regarding serum vitamin D (p = 0.012), diastolic blood pressure (p <0.01), and all aspects and sub-scales of quality of life (p <0.01). Based on serum vitamin D levels, diastolic blood pressure (r = -0.266, p = 0.05) was significantly negative in the case group and related to physical function areas (r = 0.638, p = 0.000) General health (r = 0.391, p = 0.000) and below were the physical health of quality of life (r = 0.366, p = 0.004) and social function (p = 0.001, r = 0.43) In case group, there was a significant positive correlation. There was no statistically significant relationship between serum vitamin D level and cytological and diastolic blood pressure and different areas of quality of life in the control group.