Study of VNTR and rs3758653 polymorphisms in DRD4 gene with the incidence of methylphenidate side effects in children with Attention deficit hyperactivity disorder

Abstract

The purpose of this study was to investigate the relationship between VNTR and rs3758653 polymorphisms in DRD4 gene with the incidence of methylphenidate complications in children with ADHD. Method: This study is a cohort study conducted in Bozorgmehr Psychiatric Clinic of Tabriz University of Medical Sciences. 140 children aged 5 to 18 years with ADHD were studied throughout the year 1396. Demographic questionnaires, K-SADS interviews, checklist of drug complications and genetic analysis were used and data were analyzed by SPSS17 software. Results: 140 patients were enrolled in the study, the most common complication (irrespective of severity) in both the fourth week and the eighth week was loss of appetite, then insomnia, nervousness and anxiety. The most common severe complications were anorexia, weight loss, insomnia and nervousness. More complications were reported in the eighth week. In the results of rs3758653 polymorphism of DRD4 gene, in children with ADHD, the genotype TC was more and less CC genotype was observed. In the study of VNTR in 3 exon of DRD4 gene, all of the patients studied were short carriers. The most common polymorphism was type 2 repeats. Panic attacks in patients with 2 replications were significantly higher in VNTR polymorphism than in other patients (p = 0.047).