Solubility of lamotrigine in propylene glycol + ethanol and their ternary aqueous mixtures

Abstract

The solubility of lamotrigin in binary mixtures of propylene glycol (PG) + ethanol, and ternary mixtures of PG + ethanol + water at 298.2 K was reported. The measured solubility data was mathematically represented using the Jouyban-Acree model. The accuracies of the calculated solubilities were evaluated by computing mean percentage deviation MPDs (±SD); the obtained MPDs were 2.9 ± 3.4% for binary and 10.4 ± 6.8% for ternary solvent mixtures. © 2014, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.