Solubility of atenolol, amiodarone HCl and lamotrigine in polyethylene glycol 200 + water mixtures in the presence of ?-cyclodextrin

Abstract

Solubilities of three drugs, i.e. atenolol, amiodarone HCl and lamotrigine in binary mixtures of polyethylene glycol 200 + water in the presence of beta-cyclodextrin (?-CD) along with the solubilities of atenolol and amiodarone HCl in this solvent mixture in the absence of ?-CD using saturating shake flask method were studied. The generated solubility data was fitted to the Jouyban-Aeree model and the solubility profile of each drug in the presence of ?-CD was compared with solubility data in the absence of ?-CD that the solubility data of lamotrigine taken from a previous paper.