Nutrigenomics, epigenetics and pain in cancer

Abstract

Pain is inevitable experience taken in everyone life, utmost dreadful, and knowledge takes long way chronicle stories to gift heals. Cancer in terms of solid tumors is associated with infiltrating malignant cells in stroma, normal tissue with secreting malignant broth containing inflammatory soup, pound of growth factors, acidic motif combined with toxic oxidants. Terminal dendrites of pain sensory nerves within normal tissue can be activated by caner-induced neuropathy syner- gize in different ranges with these malignant materials. Recent advances in molecular medicine have speculated the dynamic fact of genetic reprogramming explained in terms of epigenetic. Aberrant events within epigenetic landscape is a well-established theory to figure out every episodes of tumorogenesis, through which some neurologic alterations corresponding to cancer growth and propagation can potentiate noxious stimulus to reach a threshold of irritating pain sense which is nociception. Related receptors as nociceptors and circuits of stimulating mediators might be considered as targets of therapeutic approaches. This chapter will review the known mechanisms of pain sensory nerves and concerning epigenetic process might regulate persistent pain states and finally will review the advances of nutrition in association with genomic alterations (nutrigenomics) might be applicable in the management of chronic pain. Current results showed that neuropathy and reasons for permanent activation of nociceptive nerve fibers may cause to pathologic plasticity of nociception lead less threshold of pain signals to secondary nerve fibers. Therefore pain can persist over longer time and causes wind-up phenomenon. Very complex epigenetic reprogramming are the principle actor in neuronal plasticity. Nutrigeneomics is an active field of research explore benefits of dietary manipulation or nutraceutical components on the transcriptomics, which is being detailed in this review to elucidate the related molecular mechanisms underlie modulation of noxious stimuli and nociceptive pathways. © Springer International Publishing AG 2017. All rights reserved.