Lack of association between lipid and lipoprotein profile and menopause status in women with cardiac syndrome X

Abstract

Cardiac syndrome X (CSX) or angina pectoris is characterized by positive findings on exercise electrocardiography and normal results on coronary angiography). It frequently occurs in menopausal women. On the other hand, studies indicated that menopause is associated with alteration in lipid profile and increased risk of cardiovascular diseases. Therefore, this study aimed to determine the possible influence of menopause on lipid and lipoprotein profile in women with CSX. Fifty women with CSX (mean age: 52.4آ±7.65 years) and 50 healthy women as control (50.0آ±5.62 years) were studied. CSX and control groups were divided as pre- and post-menopause subgroups. The plasma lipid and lipoprotein profile of subjects was estimated colorimetrically. The total cholesterol (TC), triglyceride (TG), lipoprotein A(LP[a]), low density lipoprotein (LDL), high density lipoprotein (HDL), apoprotein A1(APOA1), apoprotein B (APOB) were significantly higher among those in the CSX group than those of the control group. (TC: 158.2آ±5.7 vs. 114.5آ±5.1mg/dl; P=0.001, (TG: 152.1آ±11.4 vs. 105.9آ±8.9mg/dl; P=0.002, LP[a]: 44.2آ±7.9 vs. 22.2آ±4.3mg/dl; P=0.017, LDL: 88.9آ±3.7 vs. 66.1آ±23.4mg/dl; P=0.001, HDL: 36آ±1.4 vs. 29.3آ±0.8mg/dl; P=0.001, APOA1: 120.9آ±1.6 vs. 107.7آ±1.5mg/dl; P=0.001, and APOB: 95.2آ±3.4 vs. 74.4آ±2.6mg/dl; P=0.001). The differences of lipid and lipoprotein profile between pre-and post-menopause CSX was not significant. In conclusion, plasma lipid disorders play important roles in the development of CSX. Changes that occur in the lipid profile after menopause are not associated with increased CSX. é 2016, Science and Technology Information Institute. All rights reserved.