Evaluation of Carbinoxamine effect on improvement of orally ketamine influence on CNS suppression in animal model

Abstract

Ketamine is a suitable injectable anesthetic in human and animal that has a low intestinal absorption rate. It's bioavailability in human with oral administration is %20آ±7 and with rectal administration in cat is %43.5آ±6.1. This drug has some side effects such as hypertension, histamine releasing effects, hallucination, hyper salivation (especially with oral administration) and etc. Carbinoxamine is one potent antihistamines with anticholinergic effects that can pass trough blood-brain barrier and cause suppression of CNS. Then it seems that co administration of Carbinoxamine and ketamine cause more effective and deep CNS depression effects. The aim of this study was evaluation of ketamine and Carbinoxamine CNS suppression effects in the manner of single and concomitant in cat. Ten mixed bred male & mature cats received mentioned drugs as oral route. In 2nd stage they received concomitant doses of Carbinoxamine & ketamine in the manner of mentioned method. Each animal was monitored continuously by educated experts for CNS depression signs as graded on the behavioral scales. Carbinoxamine in sub lingual administration in high doses cause only a partial ataxia. But ketamine in different doses showed a significant dose dependent effect. Concomitant administration of Carbinoxamine with ketamine improved depth & duration of CNS depression in comparison of single administration of ketamine. Results showed that a strong and long time CNS depression is achieved when they used orally.