Effect of L-Carnitine supplementation on serum adipokines (Leptin and Visfatin) levels in obese type II diabetes mellitus women with Hypocaloric diet

Abstract

Background: Obesity is reaching epidemic proportions worldwide and correlated with various comorbidities such as diabetes mellitus, fatty liver and cardiovascular diseases. Diabetes and obesity are combined with such frequency that it has been proposed for the term Diabesity. Carnitine in high doses has no side effects of other anti-obesity drugs. In this regard, we evaluated the effect of l-carnitine supplementation on serum leptin and visfatin levels (that almost are secreted from central and peripheral fat respectively) as markers of endothelial dysfunction. Methods and Materials: In this clinical trial, 60 obese Premenopausal females suffering type II diabetes with a BMI greater than 30 were randomly selected and divided into two groups. After measuring the weight, waist circumference and record the personal details of patients, their information about three-day food records were down in sheets. During the 8-week intervention group complement of L - carnitine (2 g daily) with low-calorie diet and the second group received placebo plus low-calorie diet. Results: Supplementation of carnitine with low calorie diet reduces anthropometric indices, serum level of leptin, visfatin and inflammatory markers (p <0.0001), whereas the reduction in mentioned factors in controls was significant, but lower than case group. Conclusion: L-carnitine supplementation has pronounced and more significant impact on levels of leptin, visfatin, inflammatory markers and anthropometric indices, especially Adiposity (abdominal fat) in patients.