Effect of Allium Cepa seeds ethanolic extract, on Serum total antioxidant in experimental induced poly cystic ovarian (PCO) rats

Abstract

Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility, affecting about 5- 10% of women in age of procreation. See antioxidants effects of Allium cepa seeds ethanol extract on experimental PCO induced by estradiol-valerat (PPA) in rats. Wistar female rat (n=60) were allocated into three groups, control (n=30), C1: an equal volume of (0.9% NaCl); C2: extract (0.3cc/rat/orally/daily); C3: Sesame oil(0.3cc/rat/orally/daily) and test groups (n=30), that subdivided into groups of 3,one group received extract supplement (0.3cc Sesame oil+ 0.3cc Allium Cepa /rat/orally/daily), second and third groups were induced PCO by single injection of estradiol-valerate (4mg/rat/IM),third group, was received extract supplement, for 60 consequence days. Animals were kept in standard conditions. In last day of study the blood samples of rats in whole groups were removed and prepared to biochemical analysis. level of TAC, Superoxide dismutase and catalase were significantly decreased in pco groups (p<0.05), these side effects in groups that received extract significantly increased (p<0.05) in comparison to control and PCO groups and level of MDA in PCO groups were significantly increased as compared to control and extract groups (p<0.05). Results revealed that administration of Allium cepa ethanol extract significantly compensation blood antioxidants level in PCO induces rats.