Development of leptospira killed whole culture vaccine using different adjuvants and evaluation of humoral immune response in hamsters
Date
2013Author
Banihashemi, R
Baradaran, B
Tebianian, M
Majidi, J
Jabbari, A
Jalali, S
Mohammadpour, H
Tadayyon, K
Sekhavati, M
Ghaderi, R
Shokri, G
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Leptospirosis is an acute infectious disease caused by Leptospira spp. that produces a broad range of health problems mainly in developing world. In several affected countries, a major attempt has been begun to find a potent and effective vaccine. This is while; the available vaccines neither perused immunological memory nor confer cross-protection. Four-week-old male hamsters were subcutaneously inoculated with four-leptospiral vaccine and four-control adjuvant through a triple-injection regiment at fortnightly intervals. Animals were bled through the saphenous vein weekly until the seventh week. We have demonstrated that adjuvant plays a fundamental role in the type and extent of the immune responses raised by leptospiral vaccination. We strongly recommend selection of alum in any formulation of leptospiral vaccine. é 2013 Banihashemi R.