Comparison of oral pantaprazol and famotidine on gasteric volume and pH in elective surgeries

Abstract

Objectives: Perianesthetic aspiration is a threating side effect, that severity of it depends on pH and volume of aspirated gastric juice. Because of the loss of consciousness while anesthesia the protective reflexes disappear and make the person in risk of aspiration. Pharmacological attempts, have been made to eliminate the risk of pulmonary aspiration. The aim of this study was Comparison of oral pantaprazol and famotidine on gastric volume and pH in elective surgeries.Methods: In a double-blind, randomized clinical trial, 120 patients candidates of elective surgery were randomized in 3 groups (control or D, pantoprnzol or P and famotidine or F groups). The patients in group D, p and f were given placebo, pantaprazole 40mg and famotidine 40mg orally at 11 pm a night before surgery respectively. After induction of anesthesia, gastric contents were aspirated and analyzed for the pH and volume.Results: PH values were 2.87آ±0.92 in group D, 4.53آ±1.29 in group P and 3.79آ±1.97 in group F. There was statistical difference between groups D, P and F (pv<0.05). The results showed a considerable decrease in the gastric volume in groups P and F comparing to group D. (p<0.05).Conclusion: We concluded that oral pantaprazole is effective in reducing gastric pH comparing to famotidine and placebo, and famotidine is effective in reducing gastric volume comparing to pantaprazol.