Breast cancer risk factors among women without family history in North West of Iran

Abstract

Breast cancer is the most common cancer among Iranian women. This study aimed to investigate risk factors for non-familial breast cancer in the northwest of Iran. A case-control study was conducted from March 2010 to March 2012 in Tabriz, Iran. Two hundred women with breast cancer and 200 age-matched healthy women were included. Demographical data and risk factor related information were collected using a short structured questionnaire. Statistical analysis was carried out using conditional logistic regression with the forward elimination method and odds ratios (ORs) with related 95% confidence intervals (CIs) were estimated. The mean آ± SD ages of cases and controls were 50.05آ±11.47 and 49.91آ±11.83 years, respectively. Multivariate analysis showed that low to moderate socioeconomic status (OR=6.19, 95%CI: 2.92-13.11), previous genital surgery (OR=3.97, 95%CI: 1.53- 10.33) and no history of miscarriage (OR=2.41, 95%CI: 1.14-5.09) were risk factors for breast cancer. These findings indicate that low to moderate socioeconomic status, previous genital surgery and no history of miscarriage are factors significantly associated with increased breast cancer risk among Iranian women within Northwest of Iran.