Assessment effect of midazolam oral liquid on alertness/sedation scale and hemodynamic parameters about pediatrics referred for minimal elective ophthalmic surgeries

Abstract

Background: Midazolam is a generic prescription medication in the benzodiazepine drugclass used for sedation before medical procedures. The aim of the present study was to assess the effects of 0.5mg/kg midazolam oral liquid (2.5mg base/1ml) on alertness/sedation and also on hemodynamic parameters about pediatrics aged 6-12y/o, referred for minimal elective ophthalmic surgeries. Methods: This is a randomized double blind clinical trial performed about 100 patients with average age of 6-12 y/o and ASA class I-II (classification of physical status by American Society of Anesthesiologists). These patients were candidate for minimal elective ophthalmic surgeries, with general anesthesia between the years Jan. 2010 till Dec. 2010. After the hospital's Ethic Committee approval, the study was conducted in Tabriz University of Medical Sciences, Tabriz, IRAN. In this study patients, evaluated in recovery room before drug administration from the point of the level of alertness/sedation, anxiety and cooperation using appropriate scoring systems. Blood pressure, pulse, electro cardiogram oxygen saturation and end tidal CO2, of the patients also monitored (baseline measurements). In the present study subjects received 0.5mg/kg of midazolam syrup half an hour before induction of anesthesia by a member of research team not aware of dose of prescribed medication. Patients postoperatively evaluated from the point of sedation, hiccoughing, hypoxemia, nausea and emesis. Data collection in the present study done using questionnaire. Descriptive statistical methods employed for statistical analysis, using SPSS software Ver. 17. Results: No significant adverse effects were observed and treatments were completed successfully. It is found that a dose of 0.5mg/kg of midazolam oral liquid could be effective in sedating of young pediatrics before minimal elective surgeries. Conclusions: It is concluded that midazolam oral liquid is a safe premedication about pediatrics before minimal elective ophthalmic surgeries.