A simple spectrophotometric method for determination of sodium diclofenac in pharmaceutical formulations

Abstract

A new, simple, rapid and accurate spectrophotometric method is proposed for determination of sodium diclofenac (SD) in pharmaceutical preparations based on its reaction with concentrated nitric acid (63% w/v). The reaction product is a yellowish compound with maximum absorbance at 380nm. The corresponding calibration curve is linear over the range of 1-30mgl-1, while the limit of detection is 0.46mgl-1. é 2005 Elsevier SAS. All rights reserved.