Investigation diffusion mechanism of beta-lactam conjugated telechelic polymers of PEG and beta-cyclodextrin as the new nanosized drug carrier devices

Abstract

Six new prodrugs including conjugated telechelic polymer of beta-cyclodextrin-poly (ethylene glycol)-beta-cyclodextrin (beta-CD-PEG-beta-CD) and or parent beta-cyclodextrin (beta-CD) were designated as the new drug carrier agents containing beta-lactam antibiotics such as ampicillin (AMP), amoxicillin (AMO) and cephalexin (CEP) prodrugs for potentially local administration pharmaceutical applications. Investigation of the drug release dynamics in buffered media with pH 7.4 showed that the drug released through the prodrug matrix with slightly deviation, follows Fickian diffusion mechanism. Using equation "log (M(t)/M(infinity)) = log k + n log t" it has revealed that the synthesized prodrugs 5a-c, 6a-c have the "n" values 0.333, 0.334, 0.390. 0.540, 0.514 and 0.473, respectively. In fact, the prodrug 6c showed the least deviation from Fickian diffusion mechanism. (C) 2008 Elsevier Ltd. All rights reserved.