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A Rapid Determination of Taurine in Human Plasma by LC

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تاریخ
2009
نویسنده
Ghandforoush-Sattari, M
Mashayekhi, S
Nemati, M
Routledge, PA
Metadata
نمایش پرونده کامل آیتم
چکیده
Taurine is an amino acid which is not incorporated into proteins but found in the cytosol of many mammalian cells, in high concentrations (2-30 mM). Increase in plasma taurine concentration has already been reported after surgical trauma, X-radiation, muscle necrosis, carbon tetrachloride-induced liver damage, and paracetamol overdose. Plasma taurine concentration was measured using LC with fluorescence detection following derivatization by o-phtalaldehyde plus 3-mercapto-propionic acid and alpha-aminobutyric acid as internal standard. Under these conditions the retention time of taurine was 10 min. This method was sensitive enough, to quantify 150 pg mL(-1) and detect 50 pg mL(-1) of taurine ranging normally between 65 and 179 mmol L(-1) (8-22 mu g mL(-1)). The validated method allowed simple determination of human plasma taurine in pharmacokinetic and biomarker studies.
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http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/50993
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