• English
    • Persian
  • Persian 
    • English
    • Persian
  • ورود
مشاهده آیتم 
  •   صفحه اصلی مخزن دانش
  • TBZMED Published Academics Works
  • Published Articles
  • مشاهده آیتم
  •   صفحه اصلی مخزن دانش
  • TBZMED Published Academics Works
  • Published Articles
  • مشاهده آیتم
JavaScript is disabled for your browser. Some features of this site may not work without it.

Biopharmaceutical classification of drugs using intrinsic dissolution rate (IDR) and rat intestinal permeability

Thumbnail
تاریخ
2009
نویسنده
Zakeri-Milani, P
Barzegar-Jalali, M
Azimi, M
Valizadeh, H
Metadata
نمایش پرونده کامل آیتم
چکیده
The solubility and dissolution rate of active ingredients are of major importance in preformulation studies of pharmaceutical dosage forms. In the present study, passively absorbed drugs are classified based on their intrinsic dissolution rate (IDR) and their intestinal permeabilities. IDR was determined by measuring the dissolution of a non-disintegrating disk of drug, and effective intestinal permeability of tested drugs in rat jejunum was determined using single perfusion technique. The obtained intrinsic dissolution rate values were in the range of 0.035-56.8 mg/min/cm(2) for tested drugs. The minimum and maximum intestinal permeabilities in rat intestine were determined to be 1.6 x 10(-5) and 2 x 10(-4) cm/s, respectively. Four classes of drugs were defined: Category I: P-eff.rat > 5 x 10(-5) (cm/s) or P-eff,P-human > 4.7 x 10(-5) (cm/s), IDR > 1 (mg/min/cm(2)), Category II: P-eff,P-rat > 5 x 10(-5) (cm/s) or P-eff,P-human > 4.7 x 10(-5) (cm/s), IDR < 1(mg/min/cm(2)), Category III: P-eff,P-rat < 5 x 10(-5) (cm/s) or P-eff,P-human < 4.7 x 10(-5) (cm/s), IDR > 1 (mg/min/cm(2)) and Category IV: P-eff,P-rat < 5 x 10(-5) (cm/s) or P-eff,P-human < 4.7 x 10(-5) (cm/s), IDR < 1 (mg/min/cm(2)). According to the results obtained and proposed classification of drugs, it is concluded that drugs Could be categorized correctly based on their IDR and intestinal permeability values. (c) 2009 Elsevier B.V. All rights reserved.
URI
http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/50936
Collections
  • Published Articles

مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
تماس با ما | Send Feedback
Theme by 
Atmire NV
 

 

مرور

همه مخزنجامعه ها و مجموعه هابراساس تاریخ انتشارنویسنده هاعنوانهاموضوعاین مجموعهبراساس تاریخ انتشارنویسنده هاعنوانهاموضوع

حساب من

ورودثبت نام

مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
تماس با ما | Send Feedback
Theme by 
Atmire NV