Differences in heart rate variability parameters before and after kidney transplantation in patients with renal failure

Abstract

Introduction: Heart Rate Variability(HRV) is defined as R-R interval changes over time and is used in assessment of sympathetic and Vagal nerve effects on sinus node and thus on the heart rate. It has been seen that HRV abnormalities is reversible after normalization of renal function in kidney transplantation even in patients with long term dialysis, the kidney transplantation had normalized the HRV. Methods: In a cross-sectional and analytical study, we evaluated the HRV changes before and after kidney transplantation in 20 patients with chronic renal failure after, changes in HRV 20 patients with chronic renal failure after achieving the inclusion criteria. The patients were followed for 6 months and the results were assessed for HRV changes and other paraclinical factors. Results: In total, 11(61.1%) of patients were male and 7 (38.9 %) were female. Mean age of patients was 42.7 +/- 25 which was in the range of 25-59 years. Between parameters of HRV in patients, only the increase in the VLF and ULF was significant which had a statistically meaningful changes in comparison with the pre transplantation period (P=0.05, P=0.01). The changes in the other parameters were not statistically significant. Conclusion: With regard to the findings of this study we can defend the theory of inhibited HRV return in hemodialysis patients after the kidney transplantation, but there is need for studies with more cases to prove and confirm this theory. [Akbarzadeh F, Safa J, Sohrabi M, Ghaffari S. Differences in heart rate variability parameters before and after kidney transplantation in patients with renal failure. Life Sci J 2012;9(4):3783-3786] (ISSN: 1097-8135). http://www.lifesciencesite.com. 561