Evaluation of correlation between serum immunoglobulin levels and extent of hepatic fibrosis in patients with chronic B hepatitis

Abstract

Background: Hypergammaglobulinaemia is a common finding in patients with chronic liver diseases. The mechanism is thought to involve reduced kupffer cell clearance of antigens delivered, resulting in stimulate activity and proliferation of stellate cells and at least fibrogenesis. The aim of this study was to evaluate the correlation between serum immunoglobulin levels and possibility of use this noninvasive markers to determination of extent of hepatic fibrosis. Methods and materials: In this sectional study 50 chronic B hepatitis patients with positive virological markers and 50 people (normal control) selected from Tabriz Emam hospital during 2006-2009 and their serum IgG, IgM, IgA, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), Total protein, total bilirubin and albumin in both groups with immunoturbidometric assay and comparison with liver biopsies specimen that scoring with modified Knodell and statistical analysis was performed. Results: Results of study show significant prediction between serum total IgG (P<0.00001) and immunoglubolins( P<0.0001) levels with extent of liver fibrosis, but similar relation with another serum markers specially IgA and IgM not found. Conclusion: Total imunoglobulins and IgG serum levels had significant independent prediction of necro inflammatory and extent of liver fibrosis bit other markers did not had this relation. Also we can use total immunoglobulins and IgG serum levels as a predictor of liver fibrosis and a noninvasive method to replacement of invasive liver biopsy method. [Rasoul Estakhri, Mohammad Hossein Somi, Abdolreza TabanSadeghi, Babak Hajipour, Faeghe Tajallayi. Evaluation of correlation between serum immunoglobulin levels and extent of hepatic fibrosis in patients with chronic B hepatitis. Life Sci J 2012;9(4):2969-2974]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 436