Compression cefazolin at cord clamping & before in section skin incision in decreasing the infectious complication in patients underwent cesarean section

Abstract

Cesarean Section (CS) is associated with a high incidence of puerperal infections. The antibiotic prophylaxis in obstetric surgery may reduce infectious complications; nevertheless antibiotic prophylaxis only has proved to be effective in women with risk factors for the occurrence of infection. The aim of this study was to determine the suitable time for antibiotic injection in CS to decrease infectious side effects. In a clinical trial in 2010, 750 patients, undergone elective cesarean section, were enrolled into the study. The population was divided into two groups: Group A, including 375 women to whom antibiotic prophylaxis was applied before skin incision and Group B, including 375 women to whom antibiotic prophylaxis was applied after umbilical cord clamping. The occurrence of endomyometritis/endometritis, wound infection, febrile morbidity, total infectious morbidity, and neonatal complications were compared. In patients of group A, 356 cases (94.9%) showed no side effects, 14 cases (3.7%) had wound infection, and 5 cases (1.3%) suffered endometritis. In patients of group B, 341 cases (90.9%) showed no side effects, 24 cases (6.4%) suffered wound infection, and 10 cases (2.7%) had endometritis (p=0.099). Injection of Cefazolin before skin incision and during clamping the cord shows no difference in incidence of infectious side effects of cesarean section, and similar results were acquired in the two groups. [Ezzatalsadat Haji Seid Javadi, Mehrnoosh Eshfahani, Omid Mashrabi. Compression cefazolin at cord clamping & before in section skin incision in decreasing the infectious complication in patients underwent cesarean section. Life Sci J 2012;9(4):1255-1257] (ISSN:1097-8135). http://www.lifesciencesite.com. 189