The relationship between the level of homocysteine in mother's serum and the intensity of preeclampsia

Abstract

Determining the relationship between maternal serum homocysteine level and severity of preeclampsia. In a cross-sectional descriptive-analytical study, maternal homocysteine level was assessed in patients with mild and severe preeclampsia. The mean level was assessed by electro-immunoassay enzyme test. No significant difference was observed in age, parity and abortion history among pregnant mothers. The mean serum homocysteine level was 5.5 +/- 1.6 in control group, 6.3 +/- 1.9 in mild preeclampsia and 8.9 +/- 4.1 in severe preeclampsia. The mean serum homocysteine level was significantly higher in women with severe preeclampsia than in control group (P<0.001), but no significant difference between normal pregnant women and those with mild preeclampsia (P=0.12). This study revealed a direct relationship between concentration of serum homocysteine and severity of preeclampsia. However, in mild preeclampsia, the concentration of serum homocysteine slightly changes with no significant difference. It is deducted that low homocysteine concentration makes slight changes to vascular endothelium. [Ezzatalsadat Haji Seid Javadi, Fatemeh Ghorbali, Mohammadreza Sarookhani, Amir Javadi, Omid Mashrabi. The relationship between the level of homocysteine in mother's serum and the intensity of preeclampsia. Life Sci J 2012;9(4):1247-1249] (ISSN:1097-8135). http://www.lifesciencesite.com. 187