Antiprotozoal effect of Allium cepa on acute renal failure caused by Toxoplasma gondii

Abstract

Renal failure is described as a decrease in glomerular filtration rate. Biochemically, renal failure is typically detected by an elevated serum creatinine level. The present study was investigated to evaluate the effects of Allium cepa on renal failure in male rats which experimentally infected by Toxoplasma gondii, RH strain. Wistar male rats (n=40) were allocated into four groups, group one received tachyzoites of T. gondii (ip) (n=10), group two received tachyzoites of T. gondii (ip) plus fresh onion juice by gavage method (n=10), group three received just fresh onion juice by gavage method (n=10) and control group (n=10) received nothing. Animals were kept in standard condition. In 30 day after inducing toxoplasma infection, 5(CC) blood were collected for serum creatinine, BUN, protein, albumin, malondialdehyde (MDA) and total antioxidant capacity (TAC) levels. Kidney tissues of rat in whole groups were removed and prepared for analysis. Serum albumin and TAC were significantly decreased in group that was infected with T. gondii, in comparison to control and onion groups. Kidneys weights in toxoplasma group significantly decreased in comparison to control group (P<0.05). This study showed that T. gondii have significantly effect on serum creatinine, albumin, blood urea nitrogen (BUN), MDA and TAC and fresh onion juice returned and treated this harmful effect, so it is suggested that eating of onion is useful in toxoplasma infection.