Correlation between body mass index (BMI) and immunologic Response to Hepatitis B Vaccine

Abstract

Problem statement: To evaluation the Correlation between body mass index (BMI) and immunologic Response to Hepatitis B Vaccine. Methods: In a cross sectional descriptive analytic study carried out on the health care Workers (HCWs) of Tabriz Shahid Madani Hospital in 20010-2011, we evaluated the immunologic response of the staff to vaccination against Hepatitis B and correlation by body mass index (BMI). Results and Conclusion: Results: 122 people (36.8%) from the studied HCWs were male and 209 people (63.2%) female. The mean Primary and secondary antibody titer in the studied HCWs were 304.07 +/- 199.98 and 369.13 +/- 169.78 IU/L. From 331 studied people, 31 (9.4%) showed no response to vaccination, 52 (15.7%) low response and 248 (74.9%) good response and after one booster dose, 7 (2.1%) showed no response to vaccination, 5 (1.5%) low response and 319 (96.4%) good response. In our study, the response rate to the vaccine has been reduced by increased weight and BMI, although this reduction was not statistically significant. Mean of Primary response antibody titer in male was significantly higher than female HCWs(P=0.011). Significant liner correlation was not found between HBsAb level and HCWs weight and BMI.