RETRACTED: Evaluation of Antiphospholipid Antibodies in Youths Suffering from Cerebral Ischemia (Retracted article. See vol. 123, pg. 597, 2013)

Abstract

Objective: Cerebral stroke in young adults is not uncommon. Venous thromboses resulting from antiphospholipid antibodies (APAs) are one of causes of stroke in youths. This study aimed at evaluating the role of APAs in young patients with ischemic strokes. Methods: In this case-control study, 25 patients with diagnosis of ischemic stroke or transient ischemia attack in case group and 40 patients in control group were studied during one year. Medical history was obtained from all the patients. Levels of anticardiolipin and antiphospholipid antibodies including both IgG and IgM, were evaluated in all patients before consuming warfarin and using ELISA method. Results: Antiphospholipid antibodies or anticardiolipin antibody was high in six (24%) patients. In the control group, only two subjects had abnormally increased amounts of at least one antibody. The difference was significant between the case and control groups (P < .05). The study demonstrated that history of at least one cerebral ischemic event was observed in two out of 6 patients (33.3%) with high APAs and two out of 19 patients (10.5%) without higher APAs. Conclusion: APAs increase risk of ischemic strokes independently or in association with other vascular risk factors.