Solubility of ranitidine hydrochloride in solvent mixtures of PEG 200, PEG 400, ethanol and propylene glycol at 25 degrees C

Abstract

Experimental solubilities of ranitidine hydrochloride in binary mixtures of ethanol (EtOH)-polyethylene glycol 200 (PEG 200), EtOH-polyethylene glycol 400 (PEG 400), EtOH-1, 2-propanediol (PG), PEG 200-PG and PG-PEG 400 and ternary mixtures of EtOH-PG-PEG 400 at 25 degrees C are reported. The measured data were fitted to the Jouyban-Acree model and the mean percentage deviations (MPD) of back-calculated solubilities for EtOH-PG, EtOH-PEG 400, EtOH-PEG 200, PG-PEG 200 and PG-PEG 400 were 3.0%, 6.3%, 2.8%, 2.2% and 2.1, respectively, and the overall MPD was 3.3%. The corresponding MPD for solubility in PG-PEG 400-EtOH mixtures was 8.4%. Also, experimental densities of the saturated solutions were measured and then fitted to the Jouyban-Acree equation with the overall MPD of 1.5%. (C) 2013 Elsevier B.V. All rights reserved.