Determination of lisinopril using beta-cyclodextrin/graphene oxide-SO3H modified glassy carbon electrode

Abstract

An electrochemical method has been successfully demonstrated for sensitive determination of lisinopril with beta-cyclodextrin-graphene oxide-SO3H composite modified glassy carbon electrode (beta-CD/GO-SO3H/GCE). Cyclic voltammetry, differential pulse voltammetry, and chronocoulometry were used to investigate the electrochemical behavior of lisinopril at beta-CD/GO-SO3H/GCE. The cyclic voltammetric results indicate that beta-CD/GO-SO3H/GCE can remarkably enhance electroactivity toward the oxidation of lisinopril in buffer solutions. The electrochemical behavior was further exploited as a sensitive detection scheme for the lisinopril determination by differential-pulse voltammetry. Under optimized conditions, the concentration range and detection limit were 0.21-190.4 and 0.11 A mu M (S/N = 3), respectively. The method was successfully applied to assay the drug in human serum.