Solubility of atenolol in ethanol plus water mixtures at various temperatures

Abstract

The experimental solubility of atenolol in ethanol + water mixtures at different temperatures (298.2, 303.2, 308.2 and 313.2 K) was reported. The solubility was calculated using five numerical methods. First, the Jouyban-Acree model (method I), its combination with the van't Hoff equation (method II) and the extended version of the Jouyban-Acree model with Abraham parameters (method III) were employed. The minimum number of data points (N) were used to train the Jouyban-Acree model (N = 11) and its combination with the van't Hoff equation (N = 22), then the obtained parameters of the models were used to calculate the solubilites at other temperatures (methods IV and V). The accuracies of the calculated solubilites were evaluated by computing mean percentage deviation (MPD). The obtained MPDs (+/-standard deviation) for methods I-V were 5.6+/-7.1, 5.1+/-4.6, 34.1+/-28.0, 10.0+/-9.6 and 6.6+/-4.8 %, respectively.