COMPARISON EFFECTIVENESS OF THE BIOADHESIVE PASTE CONTAINING LICORICE 5% WITH BIOADHESIVE PASTE WITHOUT DRUG IN THE MANAGEMENT OF RECURRENT APHTHOUS STOMATITIS

Abstract

Background: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosa diseases. The treatment of RAS is principally directed towards reducing the pain and duration of each episode of ulceration. This study evaluated the efficacy of licorice bioadhesive paste 5% to control the pain and reduce the necrotic zone and erythematose and healing time of Recurrent aphthous ulcer. Methods: We performed a randomized,double blind,clinical study. A total of 60 patients, with a history of recurrent aphthous stomatitis and currently suffering from ulceration were selected from patients referred to the School of Dentistry in Zahedan. The patients divided three groups. A) group with routin managment. B) group with Licorice bioadhesive paste 5%,C) group with bioadhesive paste without Licorice. The effects of the following variable were investigated: pain, Area of the Lesion and necrotic zone and Time of the complete healing of the ulcers. Result: Recorded data using statistical software 19spss version using test Paired T Test, T-Test student and ANOVA for repeated data assessment was performed. A significant reduction in VAS was Recorded following application of the Licorce Bioadhesive paste 5% on days 1, 3, 5 compared control and placebo groups. Licorce Bioadhesive paste 5% cause a significant reduction in the area of necrotic zone in 1,3, 5 compared with control group. Conclusion: According to the results of this study, Licorce paste can be effective in the reduction of pain and of the necrotic zone of RAS.