• English
    • Persian
    • English
    • Persian
  • English 
    • English
    • Persian
    • English
    • Persian
  • Login
View Item 
  •   KR-TBZMED Home
  • TBZMED Published Academics Works
  • Published Articles
  • View Item
  •   KR-TBZMED Home
  • TBZMED Published Academics Works
  • Published Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Effect of L-carnitine supplementation on clinical symptoms in women with osteoarthritis of the knee: A randomized, double-blind, placebo-controlled trial

Thumbnail
Date
2015
Author
Kolahi, S
Mahdavi, AM
Mahdavi, R
Lak, S
Metadata
Show full item record
Abstract
Introduction: L-carnitine has been reported to be helpful in the treatment of osteoarthritis due to its prophylactic role in cartilage degradation. The aim of this study was to investigate the effect of L-carnitine supplementation on clinical symptoms of females with knee osteoarthritis (OA). Methods: In this randomized double-blind placebo-controlled trial, 72 females with mild to moderate osteoarthritis of the knee were randomly assigned into two groups to receive 750 mg/day L-carnitine (n=36) or placebo (n=36) for 8 weeks. Clinical symptoms were assessed using the WOMAC Osteoarthritis Index and 50% improvement was considered as the threshold for clinical significance. Data were analyzed by paired t-test, independent t-test, and analysis of covariance. Results: Sixty-nine patients completed the trial. L-carnitine supplementation led to significant reduction of 46.9%, 54.1%, 48.4% and 44.4% in the WOMAC total score and sub-scores of pain, stiffness and physical function, respectively (p < 0.001); whilst in the placebo group, significant reductions were only observed in WOMAC total score and pain sub-score (p < 0.05). Comparison of changes between two groups indicated significant differences in WOMAC total score and all sub-scores (p < 0.05). These significant differences were also observed between the two groups after adjusting for baseline scores (p < 0.001). The number needed to treat (95% CI) for patients who consumed L-carnitine for at least 50% reduction in WOMAC sub-scores of pain and stiffness were 3.3 (2.0, 14.90) and 2.1 (1.6, 4.13), respectively. Discussion: Although further studies are needed to confirm positive effects of L-carnitine on clinical symptoms in knee OA patients, it seems that L-carnitine may provide a new complementary approach for patients with osteoarthritis of the knee. (C) 2015 Elsevier GmbH. All rights reserved.
URI
http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/47673
Collections
  • Published Articles

Knowledge repository of Tabriz University of Medical Sciences using DSpace software copyright © 2018  HTMLMAP
Contact Us | Send Feedback
Theme by 
Atmire NV
 

 

Browse

All of KR-TBZMEDCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Knowledge repository of Tabriz University of Medical Sciences using DSpace software copyright © 2018  HTMLMAP
Contact Us | Send Feedback
Theme by 
Atmire NV