Synthesis of supramolecular biodendrimeric beta-CD-(spacer-beta-CD)(21) via click reaction and evaluation of its application as anticancer drug delivery agent

Abstract

The per--CD dendrimer (10), having 21 -CD residues connected to the core -CD in the primary and secondary sides with encapsulation efficacy and -CDs moiety to preserve the biocompatibility properties was synthesized using click reaction. The dendritic network and -CD cavity of the obtained dendrimer were utilized to form a supramolecular compound via the formation of a host-guest inclusion complex with methotrexate (MTX) drug molecule. The MTT assay of compound 10 showed very low toxicity on T47D cancer cells. In vitro drug release investigation at pHs 7.4, 5, and 3 indicated that the release manner was remarkably pH dependent.