Physicochemical Properties and Methods to Determine the Permeability of Nanoparticles

Abstract

Recently, the unique physical and chemical properties of nanoparticles were widely studied. Nanoparticles show special properties and advantages compared to their similar larger particles. Nanoparticles have wide applications in skin drug delivery, as carrier of peptide, protein, anti-inflammatory and respiratory tract drugs. Nanotechnology is used to reduce toxicity and side effects of drugs. Many techniques are available for measuring drugs permeability but none of them can be studied the effect of all factors simultaneously unless are used intact live animals or humans. In recent years, various models such as the location of perfusion (in situ) and cell culture studies have been given. Nanoparticles in properties such as heat transfer, solubility, surface to volume ratio and so on are different in compared to their similar coarse particles. Today, most cell culture models are prepared from immortalized cell lines that have originated from normal cells or colon cancer cells. Colon cancer cells are most used due to ability to differentiate and form an integrated single layer in polarized medium. Because of the special Characteristics, nanoparticles have many uses in the cosmetics industry, Preparation of sunscreens, paints, composites, coatings and even food products and increase of their medical and biological applications is Inevitable.