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  • مشاهده آیتم
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A systematic review of GLP-1 agonists on the metabolic syndrome in women with polycystic ovaries

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تاریخ
2016
نویسنده
Niafar, M
Pourafkari, L
Porhomayon, J
Nader, N
Metadata
نمایش پرونده کامل آیتم
چکیده
Purpose Glucagon-like peptides receptor agonists are currently approved as anti-obesity agents, yet the experience with their use in polycystic ovarian syndromes (PCOS)-related obesity and insulin resistance is still limited. Methods We examined the effects of liraglutide on obesity, insulin resistance, and androgen levels in PCOS through a meta-analysis. Results Seven RCTs where women with PCOS were treated with liraglutide were identified. The variables that were examined before and after a 90-day treatment included waist circumference, body mass index (BMI), fasting insulin concentrations, insulin resistance using homeostatic model (HOMA-IR), serum testosterone, and sex hormone-binding globulin (SHBG). The analysis included 178 women. Only 172 patients had post-treatment measurements. While BMI significantly dropped by -1.65 (0.72-2.58) Kg/m(2) after 3 months treatment with liraglutide, waist circumference did not change significantly. Similarly, fasting insulin levels, insulin sensitivity, and SHBG did not change significantly. However, serum testosterone decreased by 0.29 nmol/L in 88 women (P = 0.0003). Conclusion In a limited number of the women with PCOS, BMI and serum testosterone are only variables that significantly decrease after 3 months of treatment with GLP-1 receptor agonists. Larger sample size studies with longer durations of treatment may be required to examine potential benefits of these medications in improving insulin sensitivity.
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http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/47115
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