Sensing of doxorubicin hydrochloride using graphene quantum dot modified glassy carbon electrode

Abstract

In this report, graphene quantum dot (GQD) was casted on the surface of the glassy carbon electrode and used for detection and determination of doxorubicin hydrochloride (DOX) in human plasma samples. It was found that GQD has been stably absorbed on glassy carbon electrode (GCE) by simple technique. The cyclic voltammetric results indicate that GQD modified GCE can remarkably enhance electroactivity toward the oxidation of DOX in phosphate buffer solutions. The electrochemical behavior was further exploited as a sensitive detection scheme for the DOX determination by differential-pulse voltammetry. Under optimized conditions, the concentration range and detection limit were 0.018-3.60 mu M and 0.016 mu M (S/N = 3), respectively. The method was successfully applied assay of the drug in human plasma samples. (C) 2016 Elsevier B.V. All rights reserved.