Evaluation of Serum Vitamin D Levels in Patients with Hashimoto's Thyroiditis

Abstract

Objective: Vitamin D belongs to a group of fat soluble steroids responsible for enhancing intestinal absorption of calcium, phosphate to regulate theserum calcium and phosphate, for the normal mineralization of bone, muscle contraction, nerve conduction and general cellular function. New researches suggest that vitamin D plays an important role in autoimmune diseases. Hashimato thyroiditis is the most common autoimmune disease of the thyroid gland, which is the main cause of hypothyroidism. Aim of the study: The purpose of this study was to evaluate serum levels of vitamin D in patients with Hashimoto's thyroiditis and its comparison with serum vitamin D levels in healthy control group. Methods: This was a Case-control study on 45 healthy subjects and 51 patients with Hashimoto's thyroiditis. All subjects were matched for age, sex, BMI. TSH, FT4, Anti TPO-Ab and 25 (OH) D levels were measured in blood samples. Hashimato thyroiditis was diagnosed by measuring Anti-TPO-Ab titers. Results: In this study Serum vitamin D levels were measured in 96 people and 77(79.4%) had vitamin D deficiency, 9 (9.3%) had insufficient serum levels of vitamin D and 10(10.3%) did not have any abnormalities in their serum vitamin D levels. Deficient and insufficient vitamin D levels were diagnosed in 45 patients with Hashimoto's thyroiditis and 41 of control group. Conclusion: There was no relationship between serum vitamin D levels and Hashimoto's thyroiditis in this study and also because of conflictingdata's of other studies, and the role of vitamin D in autoimmune diseaseand autoimmune nature of Hashimoto's thyroiditis, for evaluation of likelihood of serum vitamin D level in relation with Hashimoto's thyroiditis more studies at vast societies are needed.