Magnetic Mesoporous Silica/Chitosan/Polyproline: A Novel Nanocomposite Toward Sensing of Some Clinically Relevant Biomolecules

Abstract

In this paper, free-radical polymerization inside magnetic mesoporous silica has been investigated in order to open a route to functional polymer-silica composite nanomaterials with well-defined mesoporosity. Proline monomers integrated with chitosan (CS) were electropolymerized into amino-functionalized magnetic mesoporous silica. The fabrication of polyproline-amino-functionalized magnetic mesoporous silica-CS nanohybrid on glassy carbon electrode ( GCE) was performed using one step electrodeposition regime. Field emission scanning electron microscopy (FE-SEM) was confirmed as produced nanohybrid material containing polyproline (PPR) into the pores of magnetic (Fe3O4) mobile crystalline material-41 grafted with 3-aminopropyl groups (MMS) which leads to increase of surface coverage of PPR. The results indicate that PPR was successfully generated inside the pores of the amino-functionalized Mobil Composition of Matter No. 41 (nPrNH(2)-MCM-41) and that the amine group was capable of protonating the polymer, producing polyproline, the most conductive one, without the addition of another acid source during the polymerization step. Therefore, it was evaluated some electrochemical aspects of the prepared nanohybrid using cyclic voltammetry, differential pulse voltammetry and linear sweep voltammetry. Finally, the electroactivity of polyproline -Fe3O4-nPrNH(2)-MCM-41-chitosan nanohybrid (PPR-MMS-CS) modified GCE toward detection and determination of some clinically relevant small biomolecules was studied.