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  • مشاهده آیتم
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Co-delivery of insulin-like growth factor 1 receptor specific siRNA and doxorubicin using chitosan-based nanoparticles enhanced anticancer efficacy in A549 lung cancer cell line

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تاریخ
2018
نویسنده
Shali, H
Shabani, M
Pourgholi, F
Hajivalili, M
Aghebati-Maleki, L
Jadidi-Niaragh, F
Baradaran, B
Akbari, AAM
Younesi, V
Yousefi, M
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نمایش پرونده کامل آیتم
چکیده
Here, we investigated the effects of dual delivery of IGF-1R siRNA and doxorubicin by chitosan nanoparticles on viability of A549 lung cancer cells line by utilization of MTT and qRT-PCR. Furthermore apoptosis and migration of treated cells were assessed by Annexin-PI and wound healing assays, respectively. The chitosan nanoparticles had about 176nm size with zeta potential and polydispersive index about 11mV and 0.3, respectively. The IGF-1R siRNA had synergistic effect on DOX-induced cytotoxicity and apoptosis in tumour cells. In addition, siRNA/DOX-loaded chitosan nanoparticles could significantly decrease migration and expressions of mmp9, VEGF and STAT3 in A549 cells.
URI
http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/44904
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