Development of Novel Doxorubicin Loaded Biodegradable Polymeric Nanofibers as the Anticancer Drug Delivery Systems

Abstract

Through the present research, for the first time, doxorubicin hydrochloride (DOX)-loaded poly (epsilon-caprolactone)-poly (ethylene glycol)-poly (epsilon-caprolactone) (PCL-PEG-PCL, PCEC) nanofibers were obtained by blending electrospinning method. The physicochemical characteristics of the DOX/PCEC nanofibers were fully evaluated. Nanofibers had homogeneous morphology with mean diameters ranging from 80 to 300 nm. The drug releasing behavior showed the faster release rate by increasing the drug content in nanofibers. The in vitro release profile and release kinetics from the DOX/PCEC nanofibers confirmed that the release profile followed Korsmeyer-Peppas model suggesting a Fickian diffusion as a major drug release mechanism.