Risk of Lung Cancer and Genetic Variations of TERT and CLPTM1L Genes: A Case-Control Study in an Iranian Population

Abstract

Genetic variants in chromosome 5p15.33 locus which is comprised of telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes were correlated with the susceptibility to lung cancer in several populations. The current study aimed to examine the frequency and also the association between two significant SNPs of TERT-CLPTM1L region and lung cancer in an Iranian population. The researchers carried out a case-control study, including 266 lung cancer patients and 250 cancer-free healthy controls matched for age, sex, and smoking status to test associations between TERT rs2736098 and CLPTM1L rs401681 polymorphisms, and lung cancer incidence in an Iranian population. The results revealed that the TERT rs2736098 T allele carriers were positively associated with lung cancer, especially lung adenocarcinoma. In contrast, T allele carriers of CLPTM1L were inversely associated with lung cancer and adenocarcinoma.