Risk of gastric cancer in association with Helicobacter pylori different virulence factors: A systematic review and meta-analysis

Abstract

Introduction: It has been proposed that specific analysis of Helicobacter pylori virulence factors can be suitable for predicting of post H. pylori infection disorders like gastric cancer (GC). The present study was designed to evaluate the association between different virulence factors of H. pylori and GC. Methods: Studies investigated the association between virulence factors of H. pylori and GC were collected from the several databases. All analysis was performed by Comprehensive Meta -Analysis V2.2 software (Biostat, Englewood, NJ, USA). Results: Based on a comprehensive literature search, 25 eligible studies were included for meta-analyses. Infection with cagA-and vacA slml-positive H. pylori strains were significantly associated with increased risk of GC (OR of [2.82 (95% CI 1.96-4.06), P < 0.001]) and ([1.75 (95% CI 1.04-2.96), P 0.034)1, respectively. Conclusions: Infection by H. pylori strains with positive vacA slml and the cagA genes can significantly increase the risk of GC. The association between the vacA slml and the cagA and GC, suggests that screening of these genes may be helpful for identifying populations at higher risk for GC.