• English
    • Persian
    • English
    • Persian
  • Persian 
    • English
    • Persian
    • English
    • Persian
  • ورود
مشاهده آیتم 
  •   صفحه اصلی مخزن دانش
  • TBZMED Published Academics Works
  • Published Articles
  • مشاهده آیتم
  •   صفحه اصلی مخزن دانش
  • TBZMED Published Academics Works
  • Published Articles
  • مشاهده آیتم
JavaScript is disabled for your browser. Some features of this site may not work without it.

Permissive role of cytosolic pH acidification in neurodegeneration: A closer look at its causes and consequences.

Thumbnail
تاریخ
2016
نویسنده
Majdi, A
Mahmoudi, J
Sadigh-Eteghad, S
Golzari, SE
Sabermarouf, B
Reyhani-Rad, S
Metadata
نمایش پرونده کامل آیتم
چکیده
The maintenance of cytosolic pH in its physiological range is required for normal neuronal activity, and even minor alterations can have serious consequences. This Review summarizes the current understanding of the conditions that are associated with cytosolic pH disruption and that lead to abnormal cytosolic acidification. Oxidative stress results in cytosolic acidification, and this plays a crucial role in the emergence of apoptosis in protein misfolding and excitotoxicity, ultimately leading to irreversible neuronal damage. Through the identification of mechanisms by which intraneuronal pH acidification promotes neurodegeneration, we may identify new approaches for preventing and treating neurodegenerative disorders. é 2016 Wiley Periodicals, Inc.
URI
http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/39900
Collections
  • Published Articles

مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
تماس با ما | Send Feedback
Theme by 
Atmire NV
 

 

مرور

همه مخزنجامعه ها و مجموعه هابراساس تاریخ انتشارنویسنده هاعنوانهاموضوعاین مجموعهبراساس تاریخ انتشارنویسنده هاعنوانهاموضوع

حساب من

ورودثبت نام

مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
تماس با ما | Send Feedback
Theme by 
Atmire NV