Carboxymethylcellulose capsulated Cu-based metal-organic framework-drug nanohybrid as a pH-sensitive nanocomposite for ibuprofen oral delivery.

Abstract

Due to non-invasive nature of oral delivery and the fact that avoids patient pain and discomfort, so the oral method is one of the most commonly used. By consideration this aim, Cu-based metal-organic framework encapsulated ibuprofen (IBU) drug nanohybrid (Cu-MOF@Drug) protected with pH-sensitive biopolymeric carboxymethylcellulose (CMC) as a novel nanocomposite for oral delivery system was synthesized. The prepared hydrogel bead characterized using FT-IR, BET, XRD, UV-Vis spectroscopy and SEM analysis. The drug release tests showed that the CMC capsulated Cu-MOF@IBU nanocomposite hydrogel bead (CMC/Cu-MOF@IBU) has a better protection against stomach pH and extended the stability of drug dosing indeed it provides a controlled release in the gastrointestinal tract conditions. The MTT test demonstrated that the CMC/Cu-MOF@IBU has low toxicity against Caco-2 cells. According to the obtained results, the hydrogel bead could potentially use as an oral drug delivery system.