The Pulmonary Artery-Aorta ratio: Is it related to quality of life in chronic obstructive pulmonary disease?

Abstract

Little is known about the relationship between health status and pulmonary artery diameter in chronic obstructive pulmonary disease (COPD) patients. The aim of this study was to evaluate correlation between Pulmonary artery-Aorta ratio (P-A ratio) and health status of the individuals, using COPD assessment test (CAT).In a cross-sectional study, 112 COPD patients were recruited. The severity of COPD was determined by global initiative for obstructive lung disease (GOLD). After digital chest CT scan, the P-A ratio was measured at the level of bifurcation and compared with CAT score, GOLD stage, exacerbation rate and Modified Medical Research Council (MMRC) score.The average P-A ratio was 0.89آ±0.16 and 62.5% of patients had ratio less than one. The P-A ratio correlates significantly with different GOLD stages, CAT score and MMRC score (P<0.001, P<0.001, P<0.001 respectively). Compared patients with low P-A ratio (<1), those with high P-A ratio (? 1) showed higher CAT score [11.94آ±5.94 vs. 25.17آ±5.84] (P<0.001). The P-A ratio was significantly higher in frequent (?2) comparing low (<2) exacerbations [1.07آ±0.07 vs. 0.77آ±0.06] (P<0.001).Significant correlations were found between P-A ratio and GOLD, exacerbation rate and health status, using CAT of patients with COPD. These findings also may suggest the potential role of P-A ratio, in the management of COPD patients. This article is protected by copyright. All rights reserved.