مطالعه حل پذیری داروی بوسنتان در مخلوط آب کمک حلال

Abstract

اسپکتروفتومتر در طولموج 267 نانومتر تعیین گردید. همچنین دادهها به مدلهای حلالیت مشترک همبسته شدند.یافتهها حلپذیری داروی بوسنتان با افزایش غلظت کمکحلال پروپیلنگلیکول افزایش مییابد، بهطوریکه بیشترین حلپذیری در پروپیلنگلیکول خالص مشاهده میشود و میزان خطای همبستگی دادهها به مدل جویبان- آکری و جویبان- آکری- وانتهوف برابر 6/19 و 1/18 درصد میباشد. نتیجهگیری دادههای حاصل نشان میدهد پروپیلنگلیکول کمکحلال مناسبی برای افزایش حلپذیری داروی بوسنتان میباشد. علاوه بر این دادههای حاصل همبستگی خوبی با مدلهای حلالیت مشترک دارد و درصد خطای پیشبینی به دست آمده، بیانگر قدرت پیشبینی مدل در یک محدوده قابل قبول میباشد., Bosentan (BST) is a drug with sulfonamide structure which is poorly soluble in water and is classified in class II of biopharmaceutics classification system. Solubility of a drug is one of the important physicochemical properties and cosolvency is a common method for increasing the solubility of low- soluble pharmaceuticals. A number of mathematical models have been presented for predict the solubility of drugs in water+cosolvent mixtures. One of this promising models is Jouyban-Acree model which is taking advantage of high accuracy compared with other algorithms.Aim The aim of this study was to measure Bosentan solubility in water +propylene glycol mixture at 293.2, 298.2, 303.2, 308.2 and 313.2 K and correlate of the data to mathematical cosolvency models.Method In this investigation, the solubility of Bosentan was determined by saturation shake flask method. After reaching the equilibrium condition, the saturated solutions were filtered and then diluted for spectrophotometric analysis at 267 nm and saturation concentrations were calculated using the calibration curve. Additionally, obtained data was correlated to the cosolvency models.Results Solubility of Bosentan was increased with the addition of cosolvent and the maximum amount was observed in neat propylene glycol and correlation of data to Jouyban-Acree and Jouyban-Acree-Vant Hoff models can predict the corresponding solubility with a good accuracy Conclusion The results showed that propylene glycol is a good solubilizing agent for Bosentan. The capability of the developed models for solubility prediction of drugs in water-cosolvent mixtures was also confirmed. These findings are supported by acceptable mean relative deviation (MRD) values. These MRD values for Jouyban-Acree and Jouyban-Acree-Vant Hoff models are 19.6 and 18.1 respectively.