بررسی سطح ویتامینD در بیماران تحت انفارکتوس حاد میوکارد قلب در بیمارستان شهید مدنی

Abstract

Background Vitamin D is a fat soluble vitamin that has an important role in bone, intestinal and lymph nodes. Low levels of 25-hydroxy vitamin D in many cardiovascular diseases have been reported. The scientific findings have shown that there is a significant relationship between the lack of vitamin D and the incidence of hypertension, diabetes, hyperlipidemia, heart failure, coronary artery disease, myocardial infarction and stroke.Aim The purpose of this study was to evaluate vitamin D deficiency in patients with acute myocardial infarction and compare vitamin D serum levels with the severity of acute myocardial infarction.Methods All patients in this study were 88y who were randomly assigned to two groups as without increasing ST segment and with increasing ST segment in electrocardiogram, respectively. To assess the correlation between the severity of acute myocardial infarction and vitamin D serum levels, measurement of CK-MB and cTnI serum levels were carried out at the baseline, 8 and 24 hours, and then the differences were calculated. Result There was a significant inverse relationship between vitamin D serum levels of patients with the severity of acute myocardial infarction. Also, the changes of CK-MB and troponin parameters between the baseline state and 24 hours and the 8 and 24 hours, and the vitamin D serum levels showed a significant relationship.Conclusion Vitamin D levels in patients with acute myocardial infarction with elevated ST segment was different from those without elevated ST segment.The final definitive proof of cause and effect relationship between vitamin D deficiency and risk of cardiovascular disease in different populations around the world needs to be confirmed in observational studies and controlled clinical trials.. Key words Myocardial infarction, CK-MB, cTnI, ST segment