The expression of CD86 in oral lichen planus

Abstract

Lichen planus is an inflammatory mucocoutaneos disease which its prevalence is about 1-2 percent of the world population. one kind of this disease is erosive which in spite of low incidence of disease is more important for patients because of its symptoms. Immune system is involved in generating lichen planus. Although the cause is not well known, T- cells and other immuneregulating cells such as dendretic cells and langerhans cells are seen in increased numbers. T lymphocytes detect artigens on kertinocytes. these cells stimulate by signals produced by ligation to receptors of antigen presenting cells (APCs) such as dendretic cells and mediate apoptosis of keratinocytes and basement membrane destruction. CD86(cluster of differentiation) is one of these mulecoles expressed on dendretic cells and macrophages. several researchers are studied about the expression of this molecules and similar molecules in immune-mediated disease. Materials and Method: Twenty-two patients with oral lichen planus selected randomly. biopsy from oral lesions of these patients were obtained and normal marginal mucosa around of these lesions were served as controls. These biopsies were sent to the laboratory and to visualize CD86 expressing cells, IHC (Immunohistochemical) process were used. collected data were analysed by SPSS statistic software with fisher equation. Results: This study showed an increased number of CD86 expressing cells in erosive lichen planus lesions. while in normal mucosa no cells were found to express CD86(P<0/001). conclusion: high expression of CD86 in erosive lichen planus lesions shows an increased activation of APCs while these cells are inactive in normal mucosa.