The effect of non-surgical periodontal treatment on salivary and serum visfatin in generalized modorate to severe chronic periodontitis

Abstract

Visfatin is mainly secreted by visceral adipose tissue, especially by macrophages, and functions as a growth factor, a cytokine, an enzyme and a proinflammatory mediator. It has an important role in regulating the defense and immune functions. The aim of the present study was to evaluate the effect of non-surgical periodontal treatment on serum and salivary levels of visfatin in patients with generalized moderate to severe chronic periodontitis. Materials and methods. Eighteen patients with generalized moderate to severe chronic periodontitis were selected based on periodontal parameters of GI, PPD and CAL and radiographic parameters. Serum and salivary samples were collected at baseline and one month after treatment which consisted of scaling and root planing (SRP) to evaluate visfatin levels with an ELISA kit. Data were analyzed by SPSS 15, using paired t-test and PearsonEs correlation test. Results. Mean salivary and serum levels of visfatin significantly decreased after non-surgical periodontal treatment (P<0.05), with higher salivary levels of visfatin compared to its serum levels. Conclusion. Patients with generalized moderate to severe chronic periodontitis exhibited a significant decrease in their salivary and serum levels of visfatin. Therefore, visfatin can be considered an inflammatory marker and can serve as a marker to determine treatment efficacy in periodontal disease