The comparison of systemic prescription of Palifermin & Chlorhexidin mouth wash in prevention of chemotherapy-induced mucositis in children with ALL

Abstract

Oral mucositis is a condition in which oral mucosal membrane become inflammated and show ulcerations. This condition is the most common side effect of cancer therapies which has prevalence about 40% to 70%, but may increase up to 90% in children. Although various methods have been used already, the definite solution for the treatment of oral mucositis due to chemotherapy has not been proposed. Use of growth factor palifermin is one of the methods which have been evaluated in ALL. In this study we tried to show the effect of prescription palifermin in prevention and treatment of children with ALL. Methods and materials: 90 children with ALL were selected and divided randomly into two same groups. In the case group the prescription of palifermin with protocol of 3days before chemotherapy and with dosage of 60 mc/kg/day was done IV in the serum and after finishing chemotherapy this dosage was repeated for 3days. For the control group chlorhexidin mouth wash was prescribed from 3 days before chemotherapy for 14 days, 2 times every day(morning and evening) each time 10 cc of this drug rinsed in the mouth and throw out.The data of this study was statistically analyzed with two ways ANOVA. Results: There was a significant difference between case and control group (p<0.05). Test results showed that effect of palifermin and chlorhexidin in treatment and reduction of degree of chemotherapy induced-oral mucositisin children with ALL is not equal and palifermin showed better effect in reducing the incidence of mucositis in the first and second weeks. Conclusions: Despite the limitations of this study, it is concluded that palifermin is more effective in prevention of chemotherapy induced-oral mucositisin comparison with chlorhexidin